Ketamine Therapy for Treatment-Resistant Depression: A Breakthrough Option at Lonerock Clinic

Kristine Rice
Jun 11
2 min read

If you've tried multiple antidepressants and still struggle with depression, you're not alone—and there is hope. At Lonerock Clinic in Eugene-Springfield, Oregon, we offer ketamine therapy, a science-backed treatment that's transforming lives for people with treatment-resistant depression (TRD).

What Is Treatment-Resistant Depression?

Treatment-resistant depression is diagnosed when a person does not respond adequately to at least two different antidepressant medications, taken at the right dose and duration. It affects up to 30% of people with major depressive disorder.

Symptoms often include:

Persistent sadness or hopelessness
Lack of energy or motivation
Trouble concentrating or sleeping
Thoughts of self-harm or suicide

When traditional therapies don't work, it can feel defeating. But innovative therapies like ketamine are changing the landscape of care.

What Is Ketamine Therapy?

Ketamine is an FDA-approved anesthetic that has gained recognition over the last decade for its rapid-acting antidepressant effects—especially in patients who haven't found relief from standard medications.

At Lonerock Clinic, we offer two forms of ketamine therapy:

Intramuscular (IM) Ketamine Injections – Delivered in a controlled setting, monitored by experienced clinicians.
Spravato® (Esketamine) – A nasal spray version of ketamine, FDA-approved specifically for treatment-resistant depression.

Both options are administered under medical supervision in a safe, calming environment.

How Does Ketamine Work for Depression?

Unlike SSRIs or SNRIs, ketamine acts on the glutamate system in the brain.

It promotes:

Rapid neuroplasticity – helping your brain form new, healthier connections
Reduction in depressive symptoms – often within hours or days
Disruption of negative thought loops common in TRD and suicidal ideation

Many patients report significant improvement after just a few sessions, including increased mental clarity, motivation, and mood stability.

Is Ketamine Therapy Safe?

Yes—when administered in a clinical setting like Lonerock Clinic, ketamine therapy is both safe and well-tolerated.

We provide:

Medical screenings to ensure ketamine is appropriate for you
Real-time monitoring during treatment sessions
Collaborative care with your existing mental health provider or prescriber
Follow-up plans to support long-term improvement

Side effects are usually mild and temporary, such as dizziness or dissociation. Our experienced care team closely monitors each session for your comfort and safety.

Who Is a Good Candidate?

You may be a good candidate for ketamine therapy if:

You’ve tried two or more antidepressants without success
You experience severe depression or suicidal thoughts
You want to avoid the side effects or slow timeline of traditional medications
You’re under the care of a mental health provider who can help manage your overall treatment plan

We collaborate with therapists, psychiatrists, and primary care providers to ensure a team-based approach to your mental health.

Why Choose Lonerock Clinic?

Lonerock Clinic is a locally owned, patient-centered medical practice specializing in innovative mental health care. Our ketamine therapy program is:

Led by licensed medical providers with expertise in mental health and integrative care
Rooted in evidence-based protocols and national safety standards
Delivered with compassion, discretion, and respect

We understand how hard it is to keep trying. Let us walk with you toward something that works.

Get Started Today

If you're ready to explore ketamine therapy for treatment-resistant depression, we’re here to help. Schedule a consultation or learn more at LonerockClinic.com.

You deserve relief. Ketamine therapy might be the breakthrough you've been searching for.